Antimicrobial Drugs

pharmacology mcqs questions

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Which of the following is the site of action of Bacitracin? Cel...

Subject :-

pharmacology

Correct answer :- *** Hidden ***

Explanation :-

thesis at a step earlier than that inhibited by penicillin. Subsequently, it increases the efflux of ions by binding to the cell membrane. It is bactericidal. It is active agai

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2013-07-01 13:57:43
following site action Bacitracin Cell Wall Cell MembraneNucleic AcidRibosome Bacitracin ispolypeptide antibiotic acts inhibiting cell wall synthesis atstep earlier than that inhibited penicillin Subsequently increaseseffluxions binding tocell membrane Itbactericidal Itactive against gram positive organisms Neisseria and HInfluenza Ref: EssentialsMedical Pharmacology Tripathi 5th Edition Pages 62869
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Subject :-pharmacology

Topic :- Antimicrobial Drugs


All following antifungal drugs act cell membrane except: NystatinGriseofulvin Amphotericin BPolymixinB Griseofulvin acts interfering mitosis (within nucleus) does not act cell membrane also cause abnormal metaphase configuration Ref: Essentials Medical Pharmacology Tripathi 5th Edition Pages 628 716 718 .......


Subject :-pharmacology

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following most effective drug against leprae DapsoneRifampicin ClofazamineProthionamide Rifampicin only bactericidal drug amongst anti leprosy drugs can render Leprosy rapidly non contagious acts inhibiting mycobacterial DNA dependent RNA synthesis Ref: Essentials Medical Pharmacology Tripathi 5th Edition Pages 700 709-11 713 .......


What the mechanism action Nevirapine? Protease inhibitorIt

Subject :-pharmacology

Topic :- Antimicrobial Drugs


mechanism action Nevirapine Protease inhibitorIt Nucleoside reverse transcriptase inhibitorIt Non-nucleoside reverse transcriptase inhibitor Fusion inhibitor Nevirapine non-nucleoside reverse transcriptase inhibitor directly inhibits HIV reverse transcriptase without need for intracellular phosphorylation can induce cytochrome P450 enzymes and can induce their own metabolism well other drugs Side effects includes rashes nausea headache fever and elevation liver enzymes Nevirapine Delavirdine and Efavirenz NNRTIs Ref: Essentials Medical Pharmacology 5th Edition Pages 725-31 .......


Which one the following penicillin group drug penicillinase resistant?

Subject :-pharmacology

Topic :- Antimicrobial Drugs


one following penicillin group drug penicillinase resistant AmoxicillinCloxacillin Penicillin GPiperacillin Cloxacillin penicillinase resistant penicillin has isoxazole side chain that protect beta lactam ring from attack staphylococcal penicillinase also acid resistant more active than methicillin against penicillinase producing staphylococci but not against MRSA Cloxacillin incompletely absorbed from oral route 90% plasma protein bound metabolized liver and eliminated primarily kidney Ref: Essentials Medical Pharmacology 5th Edition Pages 659-661 .......


Which the following sulphonamides available oral preparation? Sulp

Subject :-pharmacology

Topic :- Antimicrobial Drugs


following sulphonamides available oral preparation SulphacetamideSulphadiazine Silver sulphadiazineMafenide Sulfadiazine sulfonamide can used orally rapidly absorbed rapidly excreted 50% plasma protein bound 20-40% acetylated has good penetration CSF brain therefore used treatment meningitis Ref: Essentials Medical Pharmacology 5th Edition Pages 641-3 .......


Which the following represent the mechanism action tetracycline? Inhibits

Subject :-pharmacology

Topic :- Antimicrobial Drugs


following represent mechanism action tetracycline Inhibits peptidyl transferaseCauses misreading mRNACauses termination peptide chain elongationBinds site and inhibits attachment tRNA Tetracyclines bacteriostatic antibiotics inhibits protein synthesis binding 30S ribosomal subunit and prevents attachment aminoacyl tRNA mRNA ribosome complex result peptide chain fails grow Ref: Essentials Medical Pharmacology 5th Edition Page 668-73 .......


Which drug does not need dose adjustment patient with creatinine clearance

Subject :-pharmacology

Topic :- Antimicrobial Drugs


drug does not need dose adjustment patient with creatinine clearance mg/min CiprofloxacinSparfloxacinLomefloxacinTrovafloxacin Dose adjustment not required for Trovafloxacin Moxifloxacin Pefloxacin and Nalidixic acid for patient with decreased creatinine clearence Trovafloxacin will cause liver damage and increase liver enzymes contraindicated patients with active liver disease Ref: Sherwood Gorbach John Bartlett Neil Blacklo (2004) Chapter “Quinolones” “Infectious Diesases” 3rd Edition Lippincott Publications USA Page 253 Kalzung 9th Edition Page 779 .......


Antipseudomonal action characteristic which the following antimicrobials?

Subject :-pharmacology

Topic :- Antimicrobial Drugs


Antipseudomonal action characteristic following antimicrobials CefopodoximeCefoperazone CefotetanCeforanide Cefoperazone 3rd generation cephalosporin active against gram positive well gram negative bacterias one the few antibiotics that have anti-pseudomonal action exerts its action inhibiting bacterial cell wall growth Main adverse effect this drug Hypothrombinemia and Disulfiram reaction Ref: Sherwood Gorbach John Bartlett Neil Blacklo (2004) Chapter “Cephalosporins” book “Infectious Diesases” 3rd Edition Lippincott Publications USA Page 196 .......


Which the following drugs cannot used patient with Multi drug resistant Tuber

Subject :-pharmacology

Topic :- Antimicrobial Drugs


following drugs cannot used patient with Multi drug resistant Tuberculosis CiprofloxacinTobramycin ClarithromycinAmikacin aminoglycoside group drug used various bacterial infection particulary gram negative exterts its action inhibiting bacterial 30S and 50S ribosome preventing formation 70S complex not used antimycobacterial Other aminoglycosides such streptomycin and amikacin used antimycobacteriasl Ref: Richard Finkel Michelle Alexia Clark Pamela Champe Luigi Cubeddu (2009) Chapter “Antimycrobials” book “Pharmacology” 4th Edition Lippincott Williams and Wilkins Publications United States Pages 399-406 Tripathy 5th Edition Pages 684 699 .......


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