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MOCK TEST 2

random mcqs questions

Questions starts with :-

What does MHC class III genes encode?a. Interleukin 2b. Beta 2 microgl...

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Correct answer :- *** Hidden ***

Explanation :-

s (C2 and C4, properdin factor B), soluble proteins, tumor necrosis factors (TNF alpha, beta), HSP 70 and the 21 hydroxylase producing gene.Genes coding for Class III MHC molecules

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2013-11-16 10:40:15
does MHC class III genes encode Interleukin Beta microglobulinc Tumor necrosis factor Complement component MHC class III genes encodes proteinsclassic and alternate complement pathways (C2 and properdin factor soluble proteins tumor necrosis factors (TNF alpha beta) HSP and21 hydroxylase producing geneGenes coding for Class III MHC molecules located inclass III region chromosome between HLAlocus andHLA DRclass III molecules not histocompatibility antigens but certain soluble molecules such complement components and tissue necrosis factorReference:TextbookImmunology Basir Pages 93-4
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major role HLA class III region genes Immune surveillanceb Transplant rejection phenomenonc Antigen presentation and eliminationd Governing susceptibility autoimmune diseasesHLA class III contains genes for early complement components and classical pathway Deficiency these early components classical pathway associated with autoimmune disease like SLE and other collagen vascular diseases These genes thus important regulating susceptibility autoimmune disease Class III genes not participate MHC restriction graft rejection components Many proteins coded MHC class III genes may involved development autoimmunity Reference:1 Textbook Immunology Basir Page 93-42 Essential Immunology Roilt Page 2623 Textbook Microbiology Ananthanarayan and Panicker 6th Edition Page 108.......


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All following statements about cells true except:a They express IgG receptorsb They MHC restricted cytotoxic cells They derived from large granular cellsd They comprise about human peripheral lymphoid cells cells kill target cells with low levels MHC class expression hence they not MHC restricted Normal cells inhibited from killing cells because all nucleated normal cells express self class MHC molecules viral infection neoplastic transformation reduces expression class molecules inhibitory signals delivered cells interrupted and lysis occurs Reference:Robbins Pathologic Basis Disease 6th Edition Page 191.......


Which the following marker used identify Memory cells?a. RAb. RBc.

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following marker used identify Memory cells RAb RBc RCd ubiquitous marker all leukocytes this detected memory/activated cells cortical thymocytes monocytes/macrophages and granulocytes Reference:Rheumatology and Immunology Therapy: Essentials Larry Moreland Page 199.......


Which the following pan-T lymphocyte marker?a. 1b. 19d.

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following pan-T lymphocyte marker 19d Lymphocytes differentiated basis cell surface markers (CD cluster differentiation markers) using monoclonal antibodies markers CD2 and TCR found all cells and referred pan cell markers CD3 cell marker found expressed thymocytes peripheral cells and cells Reference:1 Robbins Pathologic Basis Disease 6th Edition Page 6542 Immunology Infection and Immunity Gerald Bryan Pier Page 593 Textbook Neonatal Haematology Oncology Lokeshwa Page .......


Gluten sensitive enteropathy most strongly associated with which the following?a.

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Gluten sensitive enteropathy most strongly associated with following HLA DQ2 HLA DR4c HLA DQ3d Blood group 'B'95% patients with gluten sensitive enteropathy express HLA DQ2 histocompatibility antigen chromosome celiac sprue fundamental disorder sensitivity gluten small intestinal mucosa exposed gluten there intraepithelial accumulation cytotoxic cells and helper cell lamina propria Cytokines released cells turn damage intestinal enterocytes Reference:Robbins Pathologic Basis Disease 6th Edition Page 813.......


married middle aged female gives history repeated abortions for the past years.

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married middle aged female gives history repeated abortions for past years conceptus pre-natal karyogram given below does karyotype indicate Copy image from originala Klienfelter's syndromeb Turner's syndromec Down's syndrome Patau's syndrome karyogram presence one and chromosome indicate that conceptus was male and presence third chromosome 21st pair indicate trisomy Hence fetus was case Downs syndrome Reference:Robbins Pathologic Basis Disease 6th Edition Page 171.......


Hereditary retinoblastoma develop result which the following chromosomal deleti

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Hereditary retinoblastoma develop result following chromosomal deletion 13q 13p 14c 14p 13d 14q Hereditary retinoblastomas develop from deletion gene located chromosome 13q14 Retinoblastoma gene tumor suppressor gene serves break advancement cells from phase cell cycle Reference:Robbins Pathologic Basis Disease 7th Edition Pages 287 289 1372.......


albino girl gets married normal boy. What are the chances them having affect

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albino girl gets married normal boy chances them having affected child and chances having children who carriers All normalb 50% carriersc None affected all carriers 50% affected 50% carriersAlbinism autosomal recessive disorder Autosomal recessive disorders expressed only homozygous states both alleles should mutant represents normal allele represents mutant allele represents father who normal and represents mother who affected From pedigree given below all children carriers (Aa) none them affected .......


Which the following karyotype seen nineteen year old female with short stature,

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Topic :- MOCK TEST 2


following karyotype seen nineteen year old female with short stature wide spread nipples and primary amenorrhoea XX+18b XXYc XXYd Patient described question most likely case Turner’s syndrome indicated clinical features Turner's syndrome results from complete partial loss one chromosome resulting karyotype 45X primarily characterized hypogonadism phenotypic females Reference:Robbins Pathologic Basis Disease 6th Edition Page 174-5.......


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