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What is the mechanism of action of Nevirapine ?a. It is a Protease inh...

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Explanation :-

bits HIV reverse transcriptase without the need for intracellular phosphorylation. It can induce cytochrome P450 enzymes and can induce their own metabolism as well as other drugs.

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2013-11-16 10:40:15
mechanism action Nevirapine Protease inhibitorb Nucleoside reverse transcriptase inhibitorc Non-nucleoside reverse transcriptase inhibitor Fusion inhibitorNevirapine isnon-nucleoside reverse transcriptase inhibitor directly inhibits HIV reverse transcriptase withoutneed for intracellular phosphorylation can induce cytochrome P450 enzymes and can induce their own metabolism well other drugs Side effects includes rashes nausea headache fever and elevationliver enzymesNevirapine Delavirdine and Efavirenz NNRTIsReference:EssentialsMedical Pharmacology 5th Edition Pages 725-31
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Subject :-random

Topic :- MOCK TEST 2

Mineralocorticoid Receptors found all following except:a Liver Colonc Hippocampusd KidneyMineralocorticoid Receptors present epithelia Kidney Colon Sweat glands and Circumventricular organs brain But they not present liver Reference:1 Principles Pharmacology Golan (Lippincott Williams and Wilkins) 2nd Edition Page 4952 William's Endocrinology 11th Edition Page 523.......

Subject :-random

Topic :- MOCK TEST 2

following group antibiotics possess additional anti inflammatory and immunomodulatory activities Tacrolimus Polypeptide antibioticsc Fluoroquinolonesd MacrolidesTacrolimus macrolide antibiotic acts inhibiting cytokine production possess anti-inflammatory and immunomodulatory activities Mechanism: Tacrolimus binds FKBP and forms complex This then binds calcineurin and inhibits calcineurin phosphates activity Because this cannot dephosphorylate NFATc and prevents its migration into nucleus and activation cytokines Reference:Immunopharmacology Manzoor Khan Pages 91-3.......

Which one the following penicillin group drug penicillinase resistant?a. Amoxicillin

Subject :-random

Topic :- MOCK TEST 2

one following penicillin group drug penicillinase resistant Amoxicillinb Cloxacillin Penicillin PiperacillinCloxacillin penicillinase resistant penicillin has isoxazole side chain that protect beta lactam ring from attack staphylococcal penicillinase also acid resistant more active than methicillin against penicillinase producing staphylococci but not against MRSA Cloxacillin incompletely absorbed from oral route 90% plasma protein bound metabolized liver and eliminated primarily kidney Reference:Essentials Medical Pharmacology 5th Edition Pages 659-661.......

All the following drugs are classifed hallucinogens, except: LSDb. Mescalinec.

Subject :-random

Topic :- MOCK TEST 2

All following drugs classifed hallucinogens except: LSDb Mescalinec Phenhylcyclidined MethylphenidateMethylphenidate psychostimulant similar amphetamine not hallucinogen acts primarily releasing noradrenaline and dopamine brain used treatment attention-deficit hyperactivity disorder considered superior amphetamine for hyperkinetic children because causes lesser tachycardia growth retardation Side effects anorexia insomnia abdominal discomfort bowel upset Reference:Essentials Medical Pharmacology 5th Edition Pages 403 436.......

Which the following drug used the treatment antipyschotic drug-induced Parkins

Subject :-random

Topic :- MOCK TEST 2

following drug used treatment antipyschotic drug-induced Parkinsonism Anticholinergics Amantadinec Levodopad SelegilineAntipsychotic drug induced parkinsonism treated with central anticholinergic drugs They act reducing unbalanced cholinergic activity striatum parkinsonian patients These only drugs effective treatment drug induced Parkinsonism Most commonly used anticholinergic drug Trihexyphenidyl Patients with drug induced parkinsonism presents with rigidity tremor hypokinesia mask like facies and shuffling gait Symptoms usually appear between 1-4 weeks therapy and persist unless dose reduced form extrapyramidal side effect called perioral tremors ‘rabbit syndrome’ generally occurs after several therapy Reference:Essentials Medical Pharmacology 5th Edition Pages 397-8.......

patient, corneal scraping reveals narrow angled septate hyphae. Which the followin

Subject :-random

Topic :- MOCK TEST 2

patient corneal scraping reveals narrow angled septate hyphae following likely etiologic agent Mucorb Candidac Aspergillus HistoplasmaAspergillus mould with narrow angled septate hyphae Asexual conidia arranged chain carried elongated cells called sterigmata borne expanded ends conidiophores Aspergillus fumigatus common cause aspergillosis Histoplasma dimorphic fungi Mucor broad nonseptate hyphae present tissues Candida characterized presence pseudohyphae Reference:Essentials Clinical Mycology Carol Kaufmann 2nd Edition Pages 248-53.......

All the following diseases are caused Epstein Barr virus except:a. Measles Hodgki

Subject :-random

Topic :- MOCK TEST 2

All following diseases caused Epstein Barr virus except:a Measles Hodgkins lymphomac Infectious mononucleosisd Nasopharyngeal carcinomaEpstein-Barr virus causes heterophile-positive infectious mononucleosis nasopharyngeal carcinoma Burkitt's lymphoma Hodgkin's disease and cell lymphoma (in patients with immunodeficiencies) Reference:Harrison’s Principles Internal Medicine 18th Edition Chapter 181.......

CMV retinitis HIV occurs when the CD4 counts fall below which the following levels?a

Subject :-random

Topic :- MOCK TEST 2

CMV retinitis HIV occurs CD4 counts fall below following levels 100c 200d 150CMV Retinitis most common cause loss vision AIDS patients Majority cases CMV retinitis occur patients with CD4+ cell count 50/micro Therefore patients high risk CMV retinitis (CD4+ cell count 100/micro should undergo ophthalmologic examination every 3–6 months CMV retinitis usually presents painless progressive loss vision Patients may also complain blurred vision floaters and scintillations usually bilateral characteristic retinal appearance presence perivascular hemorrhage and exudate Treatment consists oral valacyclovir ganciclovir ganciclovir foscarnet with cidofovir alternative Reference:1 Textbook Microbiology Ananthanarayan and Panicker 8th Edition Page 5732 Harrison’s Principles Internal Medicine 18th Edition Chapter 189.......

Regarding HIV which the following statement not true?a. DNA retrovirus

Subject :-random

Topic :- MOCK TEST 2

Regarding HIV following statement not true DNA retrovirus Contains Reverse Transcriptasec May infect host CD4 cells other than T-lymphocytesd Causes reduction host CD4 cells late stage diseaseThe genome HIV diploid composed identical single stranded positive sense RNA copies association with viral RNA reverse transcriptase enzyme characteristic feature retroviruses Pathogenesis: virus infects cell RNA viral RNA transcribed enzyme first single stranded DNA and then double stranded DNA integrated into host cell chromosome provirus initiate viral replication directing synthesis viral RNA and other components naked virus buds outs through host cell surface membrane acquires lipoprotein envelope consist lipid derived from host cell membrane and glycoprotein virus coded spikes constitute major surface component virus binds CD4 receptors susceptible host cells transmembrane pedicle cause cell fusion Reference:Ananthanarayan and Panicker’s Textbook Microbiology 8th Edition Page 395.......

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