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Last minute quick revision mock test series for NEET PG @ Rs.980/-

Antimicrobial Drugs

pharmacology mcqs questions

Questions starts with :-

What is the mechanism of action of Nevirapine? It is a Pro...

Subject :-

pharmacology

Correct answer :- *** Hidden ***

Explanation :-

tly inhibits HIV reverse transcriptase without the need for intracellular phosphorylation. It can induce cytochrome P450 enzymes and can induce their own metabolism as well as

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2013-07-01 13:57:34
mechanism action Nevirapine Protease inhibitorIt Nucleoside reverse transcriptase inhibitorIt Non-nucleoside reverse transcriptase inhibitor Fusion inhibitor Nevirapine isnon-nucleoside reverse transcriptase inhibitor directly inhibits HIV reverse transcriptase without need for intracellular phosphorylation can induce cytochrome P450 enzymes and can induce their own metabolism well other drugs Side effects includes rashes nausea headache fever and elevationliver enzymes Nevirapine Delavirdine and Efavirenz NNRTIs Ref: EssentialsMedical Pharmacology 5th Edition Pages 725-31
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Subject :-pharmacology

Topic :- Antimicrobial Drugs


following most effective drug against leprae DapsoneRifampicin ClofazamineProthionamide Rifampicin only bactericidal drug amongst anti leprosy drugs can render Leprosy rapidly non contagious acts inhibiting mycobacterial DNA dependent RNA synthesis Ref: Essentials Medical Pharmacology Tripathi 5th Edition Pages 700 709-11 713 .......


Subject :-pharmacology

Topic :- Antimicrobial Drugs


one following penicillin group drug penicillinase resistant AmoxicillinCloxacillin Penicillin GPiperacillin Cloxacillin penicillinase resistant penicillin has isoxazole side chain that protect beta lactam ring from attack staphylococcal penicillinase also acid resistant more active than methicillin against penicillinase producing staphylococci but not against MRSA Cloxacillin incompletely absorbed from oral route 90% plasma protein bound metabolized liver and eliminated primarily kidney Ref: Essentials Medical Pharmacology 5th Edition Pages 659-661 .......


Which the following sulphonamides available oral preparation? Sulp

Subject :-pharmacology

Topic :- Antimicrobial Drugs


following sulphonamides available oral preparation SulphacetamideSulphadiazine Silver sulphadiazineMafenide Sulfadiazine sulfonamide can used orally rapidly absorbed rapidly excreted 50% plasma protein bound 20-40% acetylated has good penetration CSF brain therefore used treatment meningitis Ref: Essentials Medical Pharmacology 5th Edition Pages 641-3 .......


Which the following represent the mechanism action tetracycline? Inhibits

Subject :-pharmacology

Topic :- Antimicrobial Drugs


following represent mechanism action tetracycline Inhibits peptidyl transferaseCauses misreading mRNACauses termination peptide chain elongationBinds site and inhibits attachment tRNA Tetracyclines bacteriostatic antibiotics inhibits protein synthesis binding 30S ribosomal subunit and prevents attachment aminoacyl tRNA mRNA ribosome complex result peptide chain fails grow Ref: Essentials Medical Pharmacology 5th Edition Page 668-73 .......


Which drug does not need dose adjustment patient with creatinine clearance

Subject :-pharmacology

Topic :- Antimicrobial Drugs


drug does not need dose adjustment patient with creatinine clearance mg/min CiprofloxacinSparfloxacinLomefloxacinTrovafloxacin Dose adjustment not required for Trovafloxacin Moxifloxacin Pefloxacin and Nalidixic acid for patient with decreased creatinine clearence Trovafloxacin will cause liver damage and increase liver enzymes contraindicated patients with active liver disease Ref: Sherwood Gorbach John Bartlett Neil Blacklo (2004) Chapter “Quinolones” “Infectious Diesases” 3rd Edition Lippincott Publications USA Page 253 Kalzung 9th Edition Page 779 .......


Antipseudomonal action characteristic which the following antimicrobials?

Subject :-pharmacology

Topic :- Antimicrobial Drugs


Antipseudomonal action characteristic following antimicrobials CefopodoximeCefoperazone CefotetanCeforanide Cefoperazone 3rd generation cephalosporin active against gram positive well gram negative bacterias one the few antibiotics that have anti-pseudomonal action exerts its action inhibiting bacterial cell wall growth Main adverse effect this drug Hypothrombinemia and Disulfiram reaction Ref: Sherwood Gorbach John Bartlett Neil Blacklo (2004) Chapter “Cephalosporins” book “Infectious Diesases” 3rd Edition Lippincott Publications USA Page 196 .......


Which the following drugs cannot used patient with Multi drug resistant Tuber

Subject :-pharmacology

Topic :- Antimicrobial Drugs


following drugs cannot used patient with Multi drug resistant Tuberculosis CiprofloxacinTobramycin ClarithromycinAmikacin aminoglycoside group drug used various bacterial infection particulary gram negative exterts its action inhibiting bacterial 30S and 50S ribosome preventing formation 70S complex not used antimycobacterial Other aminoglycosides such streptomycin and amikacin used antimycobacteriasl Ref: Richard Finkel Michelle Alexia Clark Pamela Champe Luigi Cubeddu (2009) Chapter “Antimycrobials” book “Pharmacology” 4th Edition Lippincott Williams and Wilkins Publications United States Pages 399-406 Tripathy 5th Edition Pages 684 699 .......


Which the following anti-tubercular drug contraindicated pregnancy? Ethamb

Subject :-pharmacology

Topic :- Antimicrobial Drugs


following anti-tubercular drug contraindicated pregnancy EthambutolIsoniazidRifampicinStreptomycin Streptomycin bactericidal antibiotic first class drugs called aminoglycosides discovered and was first antibiotic remedy for tuberculosis derived from actinobacterium Streptomyces griseus Streptomycin cannot given orally but must administered regular intramuscular injections adverse effect this medicine ototoxicity highly contraindicated pregnancy because ototoxicity fetus Ref: Richard Finkel Michelle Alexia Clark Pamela Champe Luigi Cubeddu (2009) Chapter “Antimycrobials” book “Pharmacology” 4th Edition Lippincott Williams and Wilkins Publications United States Page 404 Tripathi 5th Edition Page 681.......


Regarding sulpha group drugs all the below statements are true, except: Sulfonam

Subject :-pharmacology

Topic :- Antimicrobial Drugs


Regarding sulpha group drugs all below statements true except: Sulfonamide may cause Kernicterus newbornSulfonamides used Norcardia infectionsCrystalluria can occur with sulfonamideSulfasalazine absorbed well from GIT Sulfasalazine usaually absorbed from small intestines Only 10% drug absorbed remaining excreted unaltered bowel Hence this drug acts locally intestine patient with inflammatory bowel disease Ref: Paul Beringer (2006) Chapter “Antiinfectives” book “Remington: Science and Practice Pharmacy” Lippincott Williams and Wilkins USA Page 1631 Tripathi 5th Edition Pages 186 643 Katzung 9th Edition Page 591 .......


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