or

Log In/Sign Up/Register


Forget Password

Enter your email id to receive password.

Captcha Not readable? Change text.

Enter the text of above image in the box below.

or

Log In/Sign Up/Register

Last minute quick revision mock test series for NEET PG @ Rs.980/-

medical news

Researchers evaluate use of human fetal progenitor tenocyte to repair tendon injuries

Tags :- , , , ,


SHARE PLEASE -
2015-08-22 07:40:01


Tendon injuries, especially those acquired while engaging in sports, are not easily healed due to the fibrous nature of tendon tissues which transmit forces from muscle to bone and protect surrounding tissues against tension and compression. Tendon injuries to wrists, knees, elbows and rotator cuffs, often from over use when playing golf or tennis, are increasingly common for both professional and amateur athletes ("weekend warriors") alike.

Previous studies in which human fetal progenitor tenocyte (hFPT) transplantation stimulated regeneration of tendons and expedited the healing process served as the impetus for a recent study conducted by a team of Swiss researchers who characterized hFPTs and evaluated their therapeutic potential.

Their study will be published in a future issue of Cell Transplantation and is currently freely available on-line as an unedited early e-pub at: http://ingentaconnect.com/content/cog/ct/pre-prints/content-CT-1447_Grognuz_et_al

"Tendon healing is always a long process," said study co-author Dr. Lee Ann Laurent-Applegate of the University Hospital of Lausanne's Department of Musculoskeletal Medicine, Switzerland. "The healing process is not perfect and the natural structure is often never attained again. The scar tissue and adhesions remain and can lead to decreased mobility and rupture."

The researchers noted that because of poor healing outcomes, new strategies in regenerative therapy are needed.

Their study reviewed previous laboratory and clinical studies in which fetal progenitor cells were used. One such study found positive results when children suffering from burns were treated with biological bandages comprised of fetal skin progenitor cells.

The current study involved developing the optimal culturing and storage procedures for hFPTs so that they can be used for tendon regeneration.

"In order for this procedure to become a viable treatment option, it is crucial to be in accordance with laws and regulations," wrote the researchers. "Tissues and cells for clinical use are stringently regulated in most countries worldwide. In the present study, the tissue was obtained as an organ donation which is registered with Swissmedic (Swiss Agency for Therapeutic Products) in a Federal Transplantation Program and its use was in accordance with the Law for Transplantation RS810.21 of Switzerland and its related directives on research with human subjects."


"The ability of hFPTs to stimulate the activity of adult tenocytes is of importance as it could lead to a more rapid healing process," said the authors. "The in vivo model chosen for further evaluation should also allow researchers to determine whether rapid regenerative healing without scarring could be attained, while assuring safety and that no immune reaction would be elicited by these particular banked fetal progenitor tenocytes."According to the researchers, their co-culture model demonstrated that hFPTs could stimulate adult tenocytes and that an increase in their activity could potentially accelerate the regenerative process. In addition, previous studies have indicated that transplanted hFTPs could potentially provide healing without scars with the absence of fibrotic tissue. An in vivo study to show safety and efficacy would be the next step to bring this cell therapy closer to the clinic, they concluded.

"The data from this study propose that not only do fetal tenocytes proliferate more rapidly than their adult counterpart, but they are also able to induce increased metabolic activity in mature cells," said Dr. Maria Carolina de Oliveira Rodrigues of the University of São Paulo, Brazil and section editor for Cell Transplantation. "In addition, it was shown that hFPTs maintained their phenotype even under osteogenic and adipogenic culture conditions-a tribute to their stability. While the study elucidates characteristics germane to the use of these cells for therapeutic purposes, in vivo studies are imperative for assessment of safety and efficacy, while also addressing potential ethical concerns."

 Leave Your Comments Below

You must Login To Leave Your Comments

Read More Similar Articles

Tags :- , ,


With the help of a vomiting machine, a new study has provided the first evidence that vomiting can send virus particles similar to those of the human norovirus airborne.The study provides the first ev.......


Yoga exercises for diabetic patients

Tags :- , , , , ,


Yoga exercises for diabetic patients (Thinkstock Photos/ Getty Images)Here are a few exercises for those who have diabetesWe have seen or heard of yoga during wonders for people. Right from children t.......


Patients can contribute to medical studies now

Tags :- , , , , ,


Moving away from traditional ways of publishing medical research studies, renowned journals around the world are now adding a human touch to research by introducing patients as reviewers.To make .......


Chronic Respiratory Disorders Create Significant Health Care Burden

Tags :- , , , , ,


Chronic Respiratory Disorders (CRDs), including asthma, chronic obstructive pulmonary disease (COPD), and chronic bronchitis create a significant health care burden in India, yet these diseases are la.......


Head and Neck Cancer Most Common Among Indian Men: Study

Tags :- , , , , , ,


Representational Image KOTA:  The 'Head and Neck cancer' is among the top most cancers affecting Indian men and the third most common ailment among women, a study by Indian Council .......


Delhi Medical Council Suspends 4 Doctors Over Negligence in Treatment

Tags :- , , , , ,


File Photo: Safdarjung Hospital in New DelhiNEW DELHI:  In the wake of alleged negligence in treatment that led to amputation of a leg of a 11-year-old boy, the Delhi Medical Council (DMC) t.......


Americans back federal funds to Planned Parenthood for health services: poll

Tags :- , , , , ,


A Planned Parenthood clinic is seen in Vista, California, August 3, 2015.Americans broadly support providing federal funding for free women's health exams, screenings and contraception services, a Reu.......


Saudi Arabia registers 21 MERS corona cases in a week

Tags :- , , , , ,


The Saudi authorities have registered 21 Middle East Respiratory Syndrome (MERS) corona virus cases in the week ending on Aug 15, media reported on Sunday.MERS, also known as Coronavirus, causes sympt.......


Tweezer Shaped Molecule That Targets HIV in Semen Prevents HIV Infection

Tags :- , , ,


New research has found that a tweezer shaped molecule that targets the human immunodeficiency virus (HIV) in semen can help prevent HIV infection and other sexually transmitted viral diseases.The rese.......


Daily coffee could improve survival for colon cancer patients

Tags :- , ,


In a new study, researchers from Dana-Farber Cancer Institute report that regular caffeinated coffee intake may be associated with significantly reduced cancer recurrence and improved survival in pati.......


Alzheimers Disease management using Ultrasound to Slow its progression

Tags :- , , , ,


The media is buzzing after recent publication of an article in the journal Science: Translational Medicine, which suggests that we can treat Alzheimer’s disease non-invasively with ultrasound. As us.......


Get Medical alerts via email - Subscribe below

Delivered by FeedBurner

AIPGMEE latest MCQs

List of our Associates and Partners





STORY OF MBBS DOST

MBBSDost was started by Dr. Vinay Yadav in year 2009. He was a medical student then and wanted to utilize his web based hobbies to start discussion on medical topics and AIPGMEE preparation. Thus MBBSdost was created as a simplediscussion based blog for AIPGMEE

This blog was instant hit amongst medical students and doctors preparing for AIPGMEE and state PG entrance exams.

Soon Online test series was started for AIPGMEE and thousands of medical students and doctors started using it. Many question from the test series started comming directly or indirectly is AIGMEE and state PG entrance exams. This furthor enhanced popularity of the website.

Over the time mbbsdost grew bigger and bigger. It became the leading website to help in preparation of medical PG exams like AIPGMEE, AIIMS-PG, PGI, JIPMER, MIMHANS, state PG entrance exams, USMLE, FMGE etc.

Today it has developed into India's largest medical education Portal.

ABOUT MBBS DOST

With more than 120,000 members MBBSdost.com is the leading medical education portal of India.
Alexa Rank us in top 11,000 India websites.

Our Facebook pages

Being a doctor has more than 165,443 likes

medical Freaks has more than 118, 745 likes

We send regular updates to more than 1 lakh suscribers through email and more than 40 thousand suscribers through whatsapp.

We help medical students and doctors by providing help in -

  1. Studies of medical college.
  2. Clinical training and skill development.
  3. Preparation of Medical PG exams.
  4. Medical Jobs.
  5. Prescription Software for Clinics and hospitals
  6. Courses after MBBS.

MBBS Dost is the Part of the Vinay Heartbeat Education Pvt Ltd.

Contact Us

Address :

Dr. Vinay Yadav, House No-94, Block-A, Nasirpur Colony, New Delhi – 110045.

Phone - +91-9953578794

Email - admin@mbbsdost.com

Follow us :

Click on Allow to get free medical alerts including Mnemonics, Clinical Updates, Medical MCQs, Treatment guidelines, Medical News etc.