NEET PG test series @Rs.980/- | 10,000 MCQs, 260 Tests.
Login/Signup
Welcome to MBBSdost.com- Leading medical education website in India.
Total Members =
1
,
7
8
,
7
4
5

medical education

Onco quiz | What is the mechanism of action of Temozolomide?

Tags :- , , , ,


SHARE PLEASE -
2018-03-19 11:50:08

Temozolomide has emerged as an agent that is active against glioblastoma  multiforme (GBM). What is the mechanism of action of this chemotherapeutic drug?

  • A.Anthracycline

  • B.Antimetabolite

  • C.Alkylating agent

  • D.Antitubulin agent

 

image/blogger-image/Onco-quiz--What-is-the-mechanism-of-action-of-Temozolomide--medical-education-19-March-2018-06-20-070.jpg

Correct Answer - C

Explanation :- Temozolomide (TMZ) is an orally administered alkylating agent of the imidazotetrazine class that is chemically related to dacarbazine. It is rapidly and completely absorbed and passes through the blood-brain barrier, creating cerebrospinal fluid concentrations that are 20% to 40% of plasma levels. The DNA repair protein MGMT removes alkyl groups from the O6  position of guanine, a target of alkylating agents, such as TMZ. In tumors, high expression of MGMT has been associated with resistance to treatment with alkylating agents. Inactivation  of the  MGMT gene by promoter methylation diminishes DNA repair activity and has been  associated with longer overall survival in patients with GBM who are treated with  alkylating agents.

 Leave Your Comments Below

You must Login To Leave Your Comments

Read More Similar Articles

Tags :- , , ,


Although both words are pronounced same but there is a lot of difference in their meaning. I see lot of new medical students using both words interchangeably. Which is wrong. Concent is a noun and .......


Course after MBBS

Tags :- , ,


Cource after MBBS Lot many cource after MBBS are provided to help medical students enhance their medical knowledge and clinical skills. While most of the medical students concentrate to prepare .......


KUSSMAUL Breathing

Tags :- , , , , ,


KUSSMAULKussmaul breathing is a deep and labored breathing pattern often associated with severe metabolic acidosis, particularly diabetic ketoacidosis (DKA) but also kidney failure. Mnemonic.......


Autosomal dominant disorders - Mnemonic

Tags :- , , ,


"Very Powerful DOMINANT Humans"V- Von willibrands disease/ Von hippel lindauP - Pseudo hypoparathyroidismD - Dystrophia myotonicaO - Osteogenesis imperfecta/Osler-weber-renduM - Marfans syndromeI - In.......


ligaments of knee

Tags :- , , , , , ,


Mnemonic - PAMLT FLOATp posterior cruciate ligamenta anterior cruciate ligamentm medial meniscusl lateral meniscust transverse ligamentf fibular collateral ligamentl ligamentum patellaeo oblique popli.......


constricted pupils and causes of pinpoint pupils

Tags :- , , ,


Miosis(constricted pupils) seen inorganophosphorous poisoningopiumPontine hemorrhagebarbituratescarbolic acidchloral hydrateAbove three cause pinpoint pupils.......


auditory pathway

Tags :- , , , ,


"Hungry Girls 8(ate) Nothing To SLIM Themselves":    Hair cellsspiral Ganglioncranial nerve 8cochlear NucleiTrapezoid body (decussation of ventra.......


FDA approves new miniaturized ICDs and cardiac resynchronization therapy defibrillators

Tags :- , , ,


The FDA has approved 4 new heart pacing devices, the Dynagen Mini and Inogen Mini ICDs and the Dynagen X4 and Inogen X4 cardiac resynchronization therapy defibrillators (CRT-Ds). The Mini ICDs are up .......


esophageal ulcers

Tags :- , , ,


1-peptic ulcer 2-traumatic ulcers due to intubation 3-tuberculous ulcer 4-uraemic ulcers5-varicose ulcers 6-ulcers due to ingestion of irritants as alcohol and corrosive acid and a.......


Ransons criteria for acute pancreatitis

Tags :- , , , , ,


Ransons criteriaRanson's criteria are useful in assessing prognosis in early acute pancreatitis. The more of the criteria are met the higher the mortality. Ranson's criteria are assessed both at admis.......


Know your ABC'S

Tags :- , , , ,


Aortic arch: major branch order "Know your ABC'S":Aortic arch gives rise to:Brachiocephalic trunkleft Common Carotidleft Subclavian Beware though trick question of 'What is first branch of aorta.......


Get Medical alerts via email - Subscribe below

Delivered by FeedBurner

AIPGMEE latest MCQs

List of our Associates and Partners

STORY OF MBBS DOST

MBBSDost was started by Dr. Vinay Yadav in year 2009. He was a medical student then and wanted to utilize his web based hobbies to start discussion on medical topics and AIPGMEE preparation. Thus MBBSdost was created as a simplediscussion based blog for AIPGMEE

This blog was instant hit amongst medical students and doctors preparing for AIPGMEE and state PG entrance exams.

Soon Online test series was started for AIPGMEE and thousands of medical students and doctors started using it. Many question from the test series started comming directly or indirectly is AIGMEE and state PG entrance exams. This furthor enhanced popularity of the website.

Over the time mbbsdost grew bigger and bigger. It became the leading website to help in preparation of medical PG exams like AIPGMEE, AIIMS-PG, PGI, JIPMER, MIMHANS, state PG entrance exams, USMLE, FMGE etc.

Today it has developed into India's largest medical education Portal.

ABOUT MBBS DOST

With more than 120,000 members MBBSdost.com is the leading medical education portal of India.
Alexa Rank us in top 11,000 India websites.

Our Facebook pages

Being a doctor has more than 165,443 likes

medical Freaks has more than 118, 745 likes

We send regular updates to more than 1 lakh suscribers through email and more than 40 thousand suscribers through whatsapp.

We help medical students and doctors by providing help in -

  1. Studies of medical college.
  2. Clinical training and skill development.
  3. Preparation of Medical PG exams.
  4. Medical Jobs.
  5. Prescription Software for Clinics and hospitals
  6. Courses after MBBS.

MBBS Dost is the Part of the Vinay Heartbeat Education Pvt Ltd.

Contact Us

Address :

Dr. Vinay Yadav, House No-94, Block-A, Nasirpur Colony, New Delhi – 110045.

Phone - +91-9953578794

Email - admin@mbbsdost.com

Follow us :

Whatsapp Medical Alerts
Free medical alerts for Medical students. Includes mnemonics, MCQs, cases studies., medical news, CME and conference info etc. Click here to start now.