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Last minute quick revision mock test series for NEET PG @ Rs.980/-

MOCK TEST 2

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A 48 year old woman was admitted with a history of weakness for two mo...

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. Histopathological examination in a case of CLL shows diffuse effacement of lymphocyte architecture by small to medium sized lymphocyes with clumped chromatin, indistinct or absen

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2013-11-16 10:40:15
year old woman was admitted with history weakness for two months examination she has enlarged cervical lymph nodes and spleen Her hemoglobin was g/dl platelet count 109/L and total leukocyte count 109/L included 80% mature lymphoid cells with coarse clumped chromatin Bone marrow revealed nodular lymphoid infiltrate peripheral blood lymphoid cells were positive for CD5 CD20 and CD23 and were negative for CD79B and FMC-7 histopathological examination lymph node this patient will most likely exhibit effacement lymph node arachitecture by:a pseudofollicular pattern with proliferation centersb monomorphic lymphoid proliferation with nodular patternc predominantly follicular patternd diffuse proliferation medium large lymphoid cells with high mitotic rate Patient inquestion stemshowing featureschronic lymphocytic leukemia Histopathological examination incaseCLL shows diffuse effacementlymphocyte architecture small medium sized lymphocyes with clumped chromatin indistinct absent nucleoli and scanty cytoplasmChronic lymphocytic leukemia (CLL) isclonal malignancyB lymphocytes Itmanifested clinically immunosuppression bone marrow failure and organ infiltration with lymphocytesReference:Current Medical Diagnosis and Treatment 2012 Chapter
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Topic :- MOCK TEST 2


The blood vessels normally does not clot because:a Vitamin antagonists present plasmab Thrombin has positive feedback plasminogenc Sodium citrate plasma chelates calcium ionsd Vascular endothelium smooth and coated with glycocalyx Blood vessels not clot because two reasons:1 Endothelial membrane coated highly charged polysaccharide called glycocalyx Due its high density glycocalyx contribute non thrombogenic properties surface intact epithelium luminal surface endothelium smooth References:1 Grays Anatomy 38th Edition Page 14562 Robbin’s Illustrated Pathology 7th Edition Page 1263 Illustrated Human and Social Biology Brian Beckett Page 724 Encyclopedia Molecular Pharmacology Volume Stefan Offermanns Page 5035 Cerebral Vasospasm Robert Loch Macdonald Page .......


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Topic :- MOCK TEST 2


Kidney biopsy from child with hemolytic uremic syndrome characteristically most likely presents features of: Thrombotic microangiopathy Proliferative glomerulonephritisc Focal segmental glomerulosclerosisd Minimal change disease hemolytic uremic syndrome there wide spread formation hyaline thrombi microcirculation composed dense aggregates platelets surrounded fibrin referred thrombotic microangiopathy This Thrombotic microangiopathy characterized thrombosis capillaries arterioles throughout body microangiopathic hemolytic anemia thrombocytopenia and renal failure Reference:1 Robbins Pathologic Basis Disease 6th Edition Page 636-72 Current Diagnosis and Treatment Pediatrics 2012 Chapter .......


Method chromatography which molecules that are negatively charged are selectively

Subject :-random

Topic :- MOCK TEST 2


Method chromatography molecules that negatively charged selectively released from stationary phase into positively charged molecules mobile phase termed Affinity chromatographyb Ion Exchange chromatography Adsorbtion chromatographyd Size Exclusion chromatographyIon exchange chromatography chromatography molecules separated basis charge Reference:1 Applications High Performance Liquid Chromatography Andrew Pryde Mary Gilbert Pages 532 Biochemistry Reginald Garrett Charles Grisham Page 127.......


Which the following lipoproteins does not move towards charged end electrophoresis?a

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following lipoproteins does not move towards charged end electrophoresis VLDLb LDLc HDLd ChylomicronsChylomicrons not move towards charged end electrophoresis they too large penetrate into resolving gel Reference:Nutrition Lipids Health and Disease Augustine Ong Etsuo Niki Page 196.......


Sphingomyelinase Deficiency seen :a. Niemann Pick disease Farber's diseasec.

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Sphingomyelinase Deficiency seen Niemann Pick disease Farber's diseasec Tay Sach diseased Krabbe diseaseNiemann Pick Disease autosomal recessively inherited disease caused deficiency sphingomyelinase enzyme leading accumulation sphingomyelin charecterised severe CNS damage mental retardation hepatospleenomegaly and cherry red spot macula Death occur years this disease Zebra bodies seen Reference:Textbook Biochemistry Vasudevan 3rd Edition Page 157.......


Branched chain keto acid decarboxylation defective :a. Maple Syrup urine disease

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Topic :- MOCK TEST 2


Branched chain keto acid decarboxylation defective Maple Syrup urine disease Hartnup diseasec Alkaptonuriad GM1 GangliosidosisBranched chain keto acids include valine leucine and isoleucine Leucine ketogenic valine glucogenic and isoleucine both glucogenic and ketogenic thiamine requiring enzymes required for decarboxylation these aminoacids defective maple syrup urine disease (MSUD) Reference:Textbook Biochemistry Vasudevan 3rd Edition Page 160.......


Inulin like fructans are used prebiotics they are non digestible. Resistance dige

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Topic :- MOCK TEST 2


Inulin like fructans used prebiotics they non digestible Resistance digestion upper tract results from Absence digestive enzyme upper GITb Beta configuration anomeric Low stomachd Presence a-osidic linkagesInulin dietary fibre its fructan with 2-60 fructose units linked via beta (1-2)bond Due this beta configuration anomeric their fructose monomers resistant digestion GIT Reference:1 Food Science and Technology Bulletin Functional Foods Glenn Gibson Page Dietary Fibre New Frontiers for Food and Health van der Kamp Julie Jones Barry Mccleary David Topping Page 1773 Functional Foods Concept Product Glenn Gibson Christine Williams Page 249.......


Initiation visual impulse associated with:a. Condensation opsin with vitamin

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Topic :- MOCK TEST 2


Initiation visual impulse associated with:a Condensation opsin with vitamin aldehydeb Photoisomerization and hydrolysis visual purple INADPd NAD light falls rhodopsin absorbed rhodopsin causing isomerization retinaldehyde from 11-cis all-trans form and conformational change opsin This results release retinaldehyde from protein and initiation nerve impulse final step hydrolysis release all-trans-retinaldehyde and opsin Reference:Harper’s Illustrated Biochemistry 28th Edition Page .......


Neutral molecules are transported by:a. Porin channelsb. Ionophoresc. Simple diffusion

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Topic :- MOCK TEST 2


Neutral molecules transported by:a Porin channelsb Ionophoresc Simple diffusion None aboveAbsence charge over molecules (Uncharged/Neutral molecules) favours their transport simple diffusion Small neutral molecules usually transported freely across plasma membranes simple diffusion Reference: Ganong's Review Medical Physiology 22nd Edition Page 312 Biochemistry Mary Campbell Shawn Farrell 7th Edition Page 2093 Harper’s Textbook Biochemistry 27th Edition Pages 108 424 433.......


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