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clinical microbiology

microbiology mcqs questions

Questions starts with :-

Which of the following toxin acts by inhibiting protein synthesis...

Subject :-

microbiology

Correct answer :- *** Hidden ***

Explanation :-

se of dysentry called Shigella dysentriae. Shiga toxin contains an enzymatic domain and 5 binding domains which bind to globotriaosylceramide (Gb3), a glycosphingolipid on the

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2013-11-16 10:17:40
following toxin acts inhibiting protein synthesis Cholera toxinLT enterotoxigenic coliPertusis toxinShiga toxin Shiga toxin also known verotoxin was first identified inmajor causedysentry called Shigella dysentriae Shiga toxin contains enzymatic domain and binding domains bind globotriaosylceramide (Gb3)glycosphingolipid onsurfacecells andcomplexinternalizedinternalized shiga toxin hydrolyse ribosomes preventing further protein synthesis Shiga toxincomposedtwo distinct peptide subunits: The first located onlargersubnitan N-glycosidase that hydrolyzes adenine from specific sitesribosomal RNA ofmammalian 60s ribosomal subunit irreversibly inhibiting protein synthesis The second isbinding site onB subunit that recognizes glycolipidstarget cell membranes (glycolipid Ref: Toxins and Hemostasis: From Bench Bedside RManjunatha Kiri Page 642-643 TextbookPathology Krishna Page 178 InteractionPathogenic Bacteria with Host Cells Virginia Clark Volume 236 Page Microorganismsfoods Microbiological SpecificationsFood Pathogens International Commission Microbiological Specifications for Food Page127
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